@article{ref1,
title="Association between anxiolytic/hypnotic drugs and suicidal thoughts or behaviors in a population-based cohort of students",
journal="Psychiatry research",
year="2020",
author="Lecat, Nicolas and Fourrier-Réglat, Annie and Montagni, Ilaria and Tzourio, Christophe and Pariente, Antoine and Verdoux, Helene and Tournier, Marie",
volume="291",
number="",
pages="e113276-e113276",
abstract="AIMS: To investigate the association between the use of anxiolytic/hypnotic drugs and suicidal thoughts and/or behavior (STB) in students.   METHODS: 12,112 participants who completed the baseline questionnaire in the i-Share cohort between April 2013 and March 2017 were included. STB were defined at inclusion as suicidal thoughts over the previous year and/or a lifetime suicide attempt. The use of prescribed anxiolytic/hypnotic drugs over the previous 3 months was measured at baseline and follow-up time points (in 2,919 students). Psychiatric disorders were assessed through validated scales. Multivariate logistic regression models were run using disease risk score.   RESULTS: At inclusion, 25.2% of students had STB and 10.3% used anxiolytics/hypnotics. STB at baseline were associated with a more frequent use of anxiolytics/hypnotics in the previous 3 months, after adjustment for covariates including anxiety, depression, sleep, impulsivity, and substance use. The use of anxiolytics/hypnotics at baseline was not associated with the occurrence, persistence or remission of STB one year later. STB at baseline were associated with a new anxiolytic/hypnotic treatment one year later.   CONCLUSIONS: Anxiolytic/hypnotic drug use was associated with STB in students independently of many risk factors of suicide and most psychiatric disorders that require such treatment, which raises drug safety concerns.<p /> <p>Language: en</p>",
language="en",
issn="0165-1781",
doi="10.1016/j.psychres.2020.113276",
url="http://dx.doi.org/10.1016/j.psychres.2020.113276"
}