@article{ref1,
title="Gamma transcranial alternating current stimulation improves mood and cognition in patients with major depression",
journal="Journal of psychiatric research",
year="2020",
author="Haller, Nikolas and Senner, Fanny and Brunoni, Andre R. and Padberg, Frank and Palm, Ulrich",
volume="130",
number="",
pages="31-34",
abstract="Major depression is one of the most common psychiatric disorders with a high rate of treatment resistance where new treatment options are urgently warranted. One of these new options are non-invasive brain stimulation techniques like transcranial magnetic or electric stimulation. One of the latter is transcranial Alternating Current Stimulation (tACS) in various frequencies. Here, we report a case series of six patients suffering from major depression treated with tACS in gamma (40 Hz) frequency. Patients were randomized to two groups, receiving either two 10-min stimulations (group 1) or a 20-min stimulation or per day (group 2) over ten days. Hamilton Depression Rating Scale and Beck Depression Inventory decreased during treatment in both study groups by 85% and 78% (group 1), or 62% and 24% respectively (group 2). <br><br>RESULTS also showed an improvement in cognitive functions assessed by word fluency and n-back test. It is hypothesized that gamma tACS could help to synchronize disturbed frequency bands in frontal and prefrontal cortex areas and thus restore dysbalanced neural connectivity in psychiatric disorders.<p /> <p>Language: en</p>",
language="en",
issn="0022-3956",
doi="10.1016/j.jpsychires.2020.07.009",
url="http://dx.doi.org/10.1016/j.jpsychires.2020.07.009"
}