@article{ref1,
title="Cannabinoid use in psychotic patients impacts inflammatory levels and their association with psychosis severity",
journal="Psychiatry research",
year="2020",
author="Gibson, Claire L. and Bassir Nia, Anahita and Spriggs, Sharron A. and DeFrancisco, Daniel and Swift, Amy and Perkel, Charles and Zhong, Xiaobo and Mazumdar, Madhu and Fernández, Nicolás and Patel, Manishkumar and Kim-Schulze, Seunghee and Hurd, Yasmin L.",
volume="293",
number="",
pages="e113380-e113380",
abstract="Inflammatory abnormalities are well-documented in individuals with chronic psychotic disorders. Particular attention has focused on interleukin-6 (IL-6) and its correlation with psychotic symptom severity. Cannabis use is associated with an increased risk of psychosis and also has immunomodulating properties. It has been hypothesized that inflammatory disturbances are a common underlying pathology between cannabis use and psychosis. We measured inflammatory markers in individuals admitted to a psychiatric unit with acute psychosis who had toxicology positive for natural and/or synthetic cannabinoids (n = 59) compared to patients with negative cannabinoid toxicology (n = 60). Psychosis severity was assessed using the Positive and Negative Syndrome Scale (PANSS). While PANSS scores were similar between groups, cannabinoid-positive participants were more likely to receive pro re nata (PRN or as-needed) medications for agitation in the psychiatric emergency room, particularly synthetic cannabinoid-positive participants. In unadjusted models, cannabinoid-positive participants had lower interferon-γ (IFN-γ) levels (p = 0.046), but this finding was not significant after adjusting for covariates and multiple comparisons. Among cannabinoid-positive participants, IL-6 levels negatively correlated with PANSS total score (p = 0.040), as well as positive (p = 0.035) and negative (p = 0.024) subscales. <br><br>RESULTS suggest inflammatory alterations among psychotic individuals with comorbid cannabinoid use.<p /> <p>Language: en</p>",
language="en",
issn="0165-1781",
doi="10.1016/j.psychres.2020.113380",
url="http://dx.doi.org/10.1016/j.psychres.2020.113380"
}