@article{ref1,
title="Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation",
journal="Clinical neurophysiology practice",
year="2020",
author="Locke, Mitchell B. and Toepp, Stephen L. and Turco, Claudia V. and Harasym, Diana H. and Rathbone, Michel P. and Noseworthy, Michael D. and Nelson, Aimee J.",
volume="5",
number="",
pages="157-164",
abstract="OBJECTIVE: It is unclear why specific individuals incur chronic symptoms following a concussion. This exploratory research aims to identify and characterize any neurophysiological differences that may exist in motor cortex function in post-concussion syndrome (PCS).   Methods: Fifteen adults with PCS and 13 healthy, non-injured adults were tested. All participants completed symptom questionnaires, and transcranial magnetic stimulation (TMS) was used to measure intracortical and transcallosal excitability and inhibition in the dominant motor cortex.   Results: Cortical silent period (p = 0.02, g = 0.96) and ipsilateral silent period (p = 0.04, g = 0.78) were shorter in the PCS group compared to the control group which may reflect reduced GABA-mediated inhibition in PCS. Furthermore, increased corticomotor excitability was observed in the left hemisphere but not the right hemisphere.   Conclusions: These data suggest that persistent neurophysiological differences are present in those with PCS. The exact contributing factors to such changes remain to be investigated by future studies.   Significance: This study provides novel evidence of lasting neurophysiological changes in PCS.<p /> <p>Language: en</p>",
language="en",
issn="2467-981X",
doi="10.1016/j.cnp.2020.07.004",
url="http://dx.doi.org/10.1016/j.cnp.2020.07.004"
}