@article{ref1,
title="Depression and suicidal thoughts in untreated and treated narcolepsy: systematic analysis",
journal="Neurology",
year="2020",
author="Barateau, Lucie and Lopez, Regis and Chenini, Sofiene and Pesenti, Carole and Rassu, Anna Laura and Jaussent, Isabelle and Dauvilliers, Yves",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVES: To assess the frequency and determinants of depressive symptoms and suicidal thoughts in adults with narcolepsy type 1 (NT1) and controls, as well as the changes after NT1 management, and the risk factors of major depressive episode (MDE) and suicide risk (SR) in NT1.   METHODS: 297 patients with NT1 (age: 39±17 years, 172 drug-free) and 346 controls (age: 38±16 years) underwent a comprehensive clinical evaluation including the Beck Depression Inventory-II (BDI-II) self-questionnaire, with one item on suicidal thoughts. 101 drug-free patients with NT1 completed the BDI-II a second time, during treatment. In 162 patients with NT1, the face-to-face Mini International Neuropsychiatric Interview (MINI) was performed to formally diagnose current MDE and SR.   RESULTS: BDI-II total scores were higher in patients with NT1 than controls, and in untreated than treated patients. Patients with moderate-severe BDI-II scores (24.9%) were less educated, more frequently obese, had more severe narcolepsy symptoms, more autonomic dysfunctions, and poorer quality of life. <br><br>RESULTS were unchanged in models adjusted for NT1 medication intake. Suicidal thoughts were more frequent in untreated patients than controls (22.7% vs 12.4%). Patients with suicidal thoughts were more likely to be men, and with more severe narcolepsy symptoms. After narcolepsy management, BDI-II total score and suicidal thoughts decreased. MDE was diagnosed in 29 (18.1%) and SR in 27 patients (16.9%).   CONCLUSIONS: Depression, depressive symptoms, suicidal thoughts and SR were frequent in patients with NT1, especially without treatment, and were associated with NT1 severity. Depressive symptoms and suicidal thoughts improved after NT1 management.<p /> <p>Language: en</p>",
language="en",
issn="0028-3878",
doi="10.1212/WNL.0000000000010737",
url="http://dx.doi.org/10.1212/WNL.0000000000010737"
}