@article{ref1,
title="The role of peripheral cortisol levels in suicide behavior: a systematic review and meta-analysis of 30 studies",
journal="Psychiatry research",
year="2020",
author="Hernández-Díaz, Yazmín and González-Castro, Thelma Beatriz and Tovilla-Zárate, Carlos Alfonso and Juárez-Rojop, Isela Esther and López-Narváez, María Lilia and Pérez-Hernández, Nonanzit and Rodríguez-Pérez, José Manuel and Genis-Mendoza, Alma Delia and Nicolini, Humberto",
volume="293",
number="",
pages="e113448-e113448",
abstract="Cortisol can be considered as one biomarker for diagnosis of suicide; nevertheless, several studies have shown conflicting results. This study aimed to evaluate the levels of cortisol in individuals with suicide behavior and controls (healthy or with other psychiatric disorders). Published articles were searched on online databases (PubMed, Scopus and EBSCO). Standardized mean differences (SMD), heterogeneity, publication bias and sensitivity were assessed using the Comprehensive Meta-Analysis (CMA) statistical software. The meta-analysis comprised 30 studies that provided 1775 cases, and 2162 controls (696 healthy individuals and 1465 individuals with other psychiatric diagnoses). The pooled results revealed that cortisol levels were higher in individuals with suicide behavior (SMD = 0.92, 95%CI = 0.26; 1.57, P = 0.006; I2 = 88%, Q < 0.001) than healthy controls. However, individuals with suicide behavior showed decreased levels of cortisol in the morning. Additionally, individuals with suicide behavior showed lower levels of cortisol than psychiatric controls (SMD = -1.79, 95%CI = -3.01; -0.58, P = 0.004, I2 = 89%, Q < 0.001). Morning cortisol levels in individuals with suicide behavior were higher than morning cortisol levels in psychiatric controls. Our updated meta-analysis suggests that peripheral levels of cortisol have a role in suicide behavior.<p /> <p>Language: en</p>",
language="en",
issn="0165-1781",
doi="10.1016/j.psychres.2020.113448",
url="http://dx.doi.org/10.1016/j.psychres.2020.113448"
}