@article{ref1,
title="Medication-related problems in older people in Catalonia: a real-world data study",
journal="Pharmacoepidemiology and drug safety",
year="2020",
author="Troncoso-Mariño, Amelia and López-Jiménez, Tomás and Roso-Llorach, Albert and Villén, Noemí and Amado-Guirado, Ester and Guisado-Clavero, Marina and Fernández-Bertolin, Sergio and Vigues, Mariona Pons and Foguet-Boreu, Quintí and Violán, Concepción",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="PURPOSE: The aim of this study was to determine medication-related problems (MRPs) in primary care patients over 65 years of age.   METHODS: Cross-sectional study based on the electronic health records of patients (65-99 years of age) visited in 284 primary health care centres during 2012 in Catalonia.   VARIABLES: age, sex, sociodemographic variables, number of drugs, kidney and liver function and MRPs (duplicate therapy, drug-drug interactions, potentially inappropriate medications [PIMs] and drugs contraindicated in chronic kidney disease and in liver diseases). Unconditional logistic regression models were used to identify the factors associated with MRPs in patients with multimorbidity.   RESULTS: 916 619 older people were included and 853 085 of them met the criteria for multimorbidity. Median age was 75 years and 57.7% of them were women. High percentages of MRPs were observed: PIMs (62.8%), contraindicated drugs in chronic kidney disease (12.1%), duplicate therapy (11.1%), contraindicated drugs in liver diseases (4.2%), and drug-drug interactions (1.0%). These numbers were higher in the subgroup of patients with ≥10 diseases. The most common PIMs were connected to drugs that increase the risk of fall (66.8%), antiulcer agents without criteria for gastroprotection (40.6%), and the combination of drugs with anticholinergic effects (39.7%). In the multivariate analysis, the variables associated with all MRPs among the patients with multimorbidity were the number of drugs and the number of visits.   CONCLUSIONS: The coexistence of multimorbidity and polypharmacy is associated with an elevated risk of MRPs in older people. Medication safety for older patients constitutes a pressing concern for health services.<p /> <p>Language: en</p>",
language="en",
issn="1053-8569",
doi="10.1002/pds.5149",
url="http://dx.doi.org/10.1002/pds.5149"
}