@article{ref1,
title="Interval-censored survival analysis of mild traumatic brain injury with outcome based neuroimaging clinical applications",
journal="Journal of concussion",
year="2020",
author="Vanier, Cheryl and Pandey, Trisha and Parikh, Shaunaq and Rodriguez, Alan and Knoblauch, Thomas and Peralta, John and Hertzler, Amanda and Ma, Leon and Nam, Ruslan and Musallam, Sami and Taylor, Hallie and Vickery, Taylor and Zhang, Yolanda and Ranzenberger, Logan and Nguyen, Andrew and Kapostasy, Mike and Asturias, Alex and Fazzini, Enrico and Snyder, Travis",
volume="4",
number="",
pages="e2059700220947194-e2059700220947194",
abstract="OBJECTIVEThe purpose of this study was to assess the relationship between MRI findings and clinical presentation and outcomes in patients following mild traumatic brain injury (mTBI). We hypothesize that imaging findings other than hemorrhages and contusions may be used to predict symptom presentation and longevity following mTBI.<br><br>METHODSPatients (n?=?250) diagnosed with mTBI and in litigation for brain injury underwent 3T magnetic resonance imaging (MRI). A retrospective chart review was performed to assess symptom presentation and improvement/resolution. To account for variable times of clinical presentation, nonuniform follow-up, and uncertainty in the dates of symptom resolution, a right censored, interval censored statistical analysis was performed. Incidence and resolution of headache, balance, cognitive deficit, fatigue, anxiety, depression, and emotional lability were compared among patients. Image findings analyzed included white matter hyperintensities (WMH), Diffusion Tensor Imaging (DTI) fractional anisotropy (FA) values, MR perfusion, auditory functional MRI (fMRI) activation, hippocampal atrophy (HA) and hippocampal asymmetry as defined by NeuroQuant ? volumetric software.<br><br>RESULTSPatients who reported LOC were significantly more likely to present with balance problems (p?<p /> <p>Language: en</p>",
language="en",
issn="2059-7002",
doi="10.1177/2059700220947194",
url="http://dx.doi.org/10.1177/2059700220947194"
}