@article{ref1,
title="The neuropsychology of epilepsy and suicide: a review",
journal="Aggression and violent behavior",
year="2020",
author="Harcourt, Scott",
volume="54",
number="",
pages="e101411-e101411",
abstract="Suicide accounts for three-quarters of violent deaths in the U.S. Epilepsy is diagnosed in 1.2% of the U.S. population. Within persons with epilepsy, the risk of suicide is 22% higher than in typical adults. Neuropsychologists are a part of epilepsy center care teams, yet to date there is no literature addressing the neuropsychology or brain-behavior relationship of suicide in persons with epilepsy. In this review, we summarized and integrated the literature on epilepsy and suicide. <br><br>FINDINGS included persons with epilepsy run a two-fold risk of suicidal behavior; risk increased with comorbidity, type of epilepsy, and neurosurgical intervention; no association was consistently evidenced between suicidality and recency of epilepsy diagnosis or duration of seizure or control, nor was a relationship confirmed between lethality of attempt and neurocognitive sequelae. <br><br>FINDINGS supported the bidirectionality of risk in epilepsy and suicidality. We reviewed potential neurobiological origins of suicide and epilepsy in the hypothalamic-pituitary-adrenal axis, hippocampus, and serotonergic, noradrenergic, and glutamatergic/GABAergic pathways, and of epilepsy in cellular plasticity, inflammatory response, and excitatory-inhibitory dysfunction. Neuropsychological theories of suicide were also reviewed. Neuropsychological domains of assessment were surveyed, and clinical implications discussed. Directions for further research were proposed.<p /> <p>Language: en</p>",
language="en",
issn="1359-1789",
doi="10.1016/j.avb.2020.101411",
url="http://dx.doi.org/10.1016/j.avb.2020.101411"
}