@article{ref1,
title="Prefrontal dysfunction associated with a history of suicide attempts among patients with recent onset schizophrenia",
journal="NPJ schizophrenia",
year="2020",
author="Matsuoka, Jun and Koike, Shinsuke and Satomura, Yoshihiro and Okada, Naohiro and Nishimura, Yukika and Sakakibara, Eisuke and Sakurada, Hanako and Yamagishi, Mika and Takahashi, Katsuyoshi and Takayanagi, Yoichiro and Kasai, Kiyoto",
volume="6",
number="1",
pages="e29-e29",
abstract="Suicide is a major cause of death in patients with schizophrenia, particularly among those with recent disease onset. Although brain imaging studies have identified the neuroanatomical correlates of suicidal behavior, functional brain activity correlates particularly in patients with recent-onset schizophrenia (ROSZ) remain unknown. Using near-infrared spectroscopy (NIRS) recording with a high-density coverage of the prefrontal area, we investigated whether prefrontal activity is altered in patients with ROSZ having a history of suicide attempts. A 52-channel NIRS system was used to examine hemodynamic changes in patients with ROSZ that had a history of suicide attempts (n = 24) or that lacked such a history (n = 62), and age- and sex-matched healthy controls (n = 119), during a block-design letter fluency task (LFT). Patients with a history of suicide attempts exhibited decreased activation in the right dorsolateral prefrontal cortex compared with those without such a history. Our findings indicate that specific regions of the prefrontal cortex may be associated with suicidal attempts, which may have implications for early intervention for psychosis.<p /> <p>Language: en</p>",
language="en",
issn="2334-265X",
doi="10.1038/s41537-020-00118-z",
url="http://dx.doi.org/10.1038/s41537-020-00118-z"
}