@article{ref1,
title="Impact of depression on gait variability in Parkinson's disease",
journal="Clinical neurology and neurosurgery",
year="2020",
author="Dragašević-Mišković, Nataša T. and Bobić, Vladislava and Kostić, Milutin and Stankovic, Iva and Radovanović, Saša and Dimitrijević, Kosta and Svetel, Marina and Petrović, Igor and Đurić-Jovičić, Milica",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVE: The goal of this study was to analyze how depression associated with Parkinson's disease (PD) affected gait variability in these patients using a dual-task paradigm. Additionally, the dependency of the executive functions and the impact of depression on gait variability were analyzed.   PATIENTS AND METHODS: Three subject groups were included: patients with PD, but no depression (PD-NonDep; 14 patients), patients with both PD and depression (PD-Dep; 16 patients) and healthy controls (HC; 15 subjects). Gait was recorded using the wireless sensors. The participants walked under four conditions: single-task, motor dual- task, cognitive dual-task, and combined dual-task. Variability of stride length, stride duration, and swing time was calculated and analyzed using the statistical methods.   RESULTS: Variability of stride duration and stride length were not significantly different between PD-Dep and PD-NonDep patients. The linear mixed model showed that swing time variability was statistically significantly higher in PD-Dep patients compared to controls (p = 0.001). Hamilton Disease Rating Scale scores were significantly correlated with the swing time variability (p = 0.01). Variability of all three parameters of gait was significantly higher while performing combined or cognitive task and this effect was more pronounced in PD-Dep group of patients.   CONCLUSIONS: Depression in PD was associated with swing time variability, and this effect was more prominent while performing a dual-task.   SIGNIFICANCE: Diagnosing and treating depression might be important for gait improvement and fall reduction in PD patients.<p /> <p>Language: en</p>",
language="en",
issn="0303-8467",
doi="10.1016/j.clineuro.2020.106324",
url="http://dx.doi.org/10.1016/j.clineuro.2020.106324"
}