@article{ref1,
title="Using machine learning-based analytics of daily activities to identify modifiable risk factors for falling in Parkinson's disease",
journal="Parkinsonism and related disorders",
year="2020",
author="Panyakaew, Pattamon and Pornputtapong, Natapol and Bhidayasiri, Roongroj",
volume="82",
number="",
pages="77-83",
abstract="BACKGROUND: Although risk factors that lead to falling in Parkinson's disease (PD) have been previously studied, the established predictors are mostly non-modifiable. A novel method for fall risk assessment may provide more insight into preventable high-risk activities to reduce future falls.   OBJECTIVES: To explore the prediction of falling in PD patients using a machine learning-based approach.   METHOD: 305 PD patients, with or without a history of falls within the past month, were recruited. Data including clinical demographics, medications, and balance confidence, scaled by the 16-item Activities-Specific Balance Confidence Scale (ABC-16), were entered into the supervised machine learning models using XGBoost to explore the prediction of fallers/recurrent fallers in two separate models.   RESULTS: 99 (32%) patients were fallers and 58 (19%) were recurrent fallers. The accuracy of the model to predict falls was 72% (p = 0.001). The most important factors were item 7 (sweeping the floor), item 5 (reaching on tiptoes), and item 12 (walking in a crowded mall) in the ABC-16 scale, followed by disease stage and duration. When recurrent falls were analysed, the models had higher accuracy (81%, p = 0.02). The strongest predictors of recurrent falls were item 12, 5, and 10 (walking across parking lot), followed by disease stage and current age.   CONCLUSION: Our machine learning-based study demonstrated that predictors of falling combined demographics of PD with environmental factors, including high-risk activities that require cognitive attention and changes in vertical and lateral orientations. This enables physicians to focus on modifiable factors and appropriately implement fall prevention strategies for individual patients.<p /> <p>Language: en</p>",
language="en",
issn="1353-8020",
doi="10.1016/j.parkreldis.2020.11.014",
url="http://dx.doi.org/10.1016/j.parkreldis.2020.11.014"
}