@article{ref1,
title="Acute phenobarbital poisoning for the management of seizures in new-borns and children; a systematic literature review",
journal="CNS and neurological disorders drug targets",
year="2020",
author="Ghorani-Azam, Adel and Balali-Mood, Mahdi and Riahi-Zanjani, Bamdad and Darchini-Maragheh, Emadodin and Sadegh, Mahmood",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVES: While phenobarbital (PB) is commonly used for the management of seizures in newborns and pediat-rics, its administration may accompany with acute poisoning. We aimed to review the literature to find out the frequency of PB poisonings in newborns and children with seizures.   METHOD: Literature search was performed by two independent reviewers to find relevant articles about PB toxicity in neo-nates and pediatrics that were treated for seizure.   RESULTS: 18 articles met the inclusion criteria and were included to this systematic review. The main reasons of PB poison-ing in studied patients were therapeutic intoxication. Reported signs of PB poisoning were lethargy, sedation, lack of suck-ing, fever, skin rash, hepatic inflammation and alopecia. Moreover, respiratory depression, encephalopathy, myocardial fail-ure, syndrome of inappropriate antidiuretic hormone, and coma were among the complications of acute PB toxicity in chil-dren and infants.   CONCLUSION: PB therapy for the management of seizures in newborns and children might be associated with poisoning. Alt-hough supportive and symptomatic treatments are available for PB overdose, it should be administered with caution, using drug monitoring to avoid toxicity.<p /> <p>Language: en</p>",
language="en",
issn="1871-5273",
doi="10.2174/1871527319666201207205916",
url="http://dx.doi.org/10.2174/1871527319666201207205916"
}