@article{ref1,
title="Comorbid cannabis use disorder with major depression and generalized anxiety  disorder: a systematic review with meta-analysis of nationally representative  epidemiological surveys",
journal="Journal of affective disorders",
year="2020",
author="Onaemo, Vivian N. and Fawehinmi, Timothy O. and D'Arcy, Carl",
volume="281",
number="",
pages="467-475",
abstract="BACKGROUND: Studies have shown a high degree of comorbidity between cannabis use  disorder (CUD) and other mental illnesses. However, there is a paucity of research  on the comorbidity between CUD with major depression (MD) and generalized anxiety  disorder (GAD). This systematic review with meta-analysis aimed to assess the  prevalence and strength of association between co-morbid CUD with MD and GAD. <br><br>METHODS: An extensive search of Medline, CINAHL, PsycINFO, EMBASE, and grey  literature were conducted to cover articles published between January 1(st), 1980,  and July 31(st), 2020. Inclusion criteria were publications in English Language,  original research, nationally representative samples, and non-clinical randomly  selected adult populations. A systematic review and meta-analysis for the prevalence  and ORs for comorbid CUD with MD or GAD were done. <br><br>RESULTS: A total of 67 articles  were identified by the electronic searches. A full-text review yielded 8  publications on nationally representative epidemiological surveys. 12-month and  lifetime comorbidity estimates were extracted and used for the meta-analysis. CUD  was strongly associated with MDE (OR 3.22; 2.31 - 4.49) and with GAD (OR 2.99; 2.14  - 4.16). LIMITATIONS: Limitations of this study include the heterogeneity observed  due to the combination of studies from different geographic regions with different  modifications of diagnostic criteria and varied response rates. This was addressed  with a random-effects model. <br><br>CONCLUSION: This review confirms the evidence of high  prevalence and a 3-fold comorbid association between CUD with MD and CUD with GAD. Implementation of evidence-based policy interventions with effective, integrated  management of comorbid CUDs with psychiatric disorders may contribute to positive  patient outcomes.<p /> <p>Language: en</p>",
language="en",
issn="0165-0327",
doi="10.1016/j.jad.2020.12.043",
url="http://dx.doi.org/10.1016/j.jad.2020.12.043"
}