@article{ref1,
title="Subanesthetic ketamine infusions for suicide ideation in patients with bipolar and  unipolar treatment refractory depression",
journal="Psychiatry research",
year="2020",
author="Kang, Melody J. Y. and Kulcar, Eugenia and Chandrasena, Ranjith and Anjum, Mah-Rukh and Fairbairn, Jonathan and Hawken, Emily R. and Vazquez, Gustavo H.",
volume="296",
number="",
pages="e113645-e113645",
abstract="We evaluated the effects of repeated subanesthetic ketamine infusions on suicidal  ideation (SI) in patients with major depression. 82 subjects with  treatment-resistant unipolar and bipolar depression completed a two-site open-label  case-series of repeated (up to four weeks) infusions of ketamine (0.5 mg/kg). Ketamine produced a significant reduction in SI as early as one hour (71.1%) and up  to 1-week post-infusion (60.4%), accompanied by a reduction in overall depressive  symptoms which were maintained until the 4(th) week. The observed anti-suicidal  effect was independent of mood changes, as patients whose mood did not respond still  exhibited significantly less SI than baseline.<p /> <p>Language: en</p>",
language="en",
issn="0165-1781",
doi="10.1016/j.psychres.2020.113645",
url="http://dx.doi.org/10.1016/j.psychres.2020.113645"
}