@article{ref1,
title="Cannabis use in college: genetic predispositions, peers, and activity participation",
journal="Drug and alcohol dependence",
year="2020",
author="Thomas, Nathaniel S. and Salvatore, Jessica E. and Gillespie, Nathan A. and Aliev, Fazil and Ksinan, Albert J. and Dick, Danielle M.",
volume="219",
number="",
pages="e108489-e108489",
abstract="BACKGROUND: Among adult college students in the US, cannabis use is common and associated with considerable negative consequences to health, cognition, and  academic functioning, underscoring the importance of identifying risk and protective  factors. Cannabis use is influenced by genetic factors, but genetic risk is not  determinative. Accordingly, it is critical to identify environments that reduce risk  among those who are at elevated genetic risk. This study examined the impact of  polygenic scores for cannabis initiation, various forms of social activity  participation, and peer deviance on recent cannabis use. Our aim was to test whether  these environments moderate genetic risk for cannabis use. <br><br>METHODS: Data came from a  longitudinal sample of undergraduate college students of European American (EA;  N(EA) = 750) and African American (AA; N(AA) = 405) ancestry. Generalized estimating  equations with a logit link function were used to examine main effects and two-way  interactions. <br><br>RESULTS: Engagement with church activities was associated with lower  probability of cannabis use. Peer deviance was associated with higher probability of  cannabis use. Engagement with community activities moderated the influence of the  polygenic risk score in the EA sample, such that PRS was associated with recent  cannabis use among those who never engaged in community activities. This effect did  not replicate in AAs, which may have been due to the portability of PRS based on EA  discovery samples. <br><br>CONCLUSIONS: Results suggest that community activities may limit  the influence of genetic risk, as associations between PRS and cannabis use were  only observed among individuals who never engaged in community activities.<p /> <p>Language: en</p>",
language="en",
issn="0376-8716",
doi="10.1016/j.drugalcdep.2020.108489",
url="http://dx.doi.org/10.1016/j.drugalcdep.2020.108489"
}