@article{ref1,
title="The feasibility of fNIRS as a diagnostic tool for pediatric TBI: a pilot study",
journal="European journal of paediatric neurology",
year="2020",
author="Da, Chung and Jj, Lenstra and Metting, Z. and Se, Rakers and Jm, Spikman and Jwj, Elting and van der Naalt, J.",
volume="30",
number="",
pages="22-24",
abstract="BACKGROUND: Functional near-infrared spectroscopy (fNIRS) enables assessment of prefrontal hemodynamic response. This study explored the feasibility of fNIRS in  determining hemodynamic changes related to cognitive task performance in pediatric  traumatic brain injury (TBI) in order to assess its potential as a diagnostic tool. <br><br>METHODS: We measured changes in oxygenated hemoglobin [O2Hb] during a verbal fluency  task (VFT), which activates frontal brain regions involved in working memory, in 15  TBI patients and 21 healthy controls using a 3-channel fNIRS system. Baseline and  absolute changes in [O2Hb] during the VFT were compared to the rest condition to  obtain effect-scores. Patients were tested in the acute phase and six weeks after  injury. Task-related fNIRS responses were categorized into positive, negative, and  no response. <br><br>RESULTS: For patients and controls, a positive response was observed in  61% (n = 22), a negative response in 19% (n = 7), and no response in 19% (n = 7). Patients showed a mean [O2Hb] effect-score of 2.18 compared to 2.52 in the control  group (p = 0.743) in the acute phase after injury. Follow-up effect-scores did not  differ significantly (p = 0.721). Decreased task performance was associated with a  higher effect-score in controls compared to decreased task performance with lower  effect-score in the patient group. <br><br>DISCUSSION: Our study shows that it is feasible  to assess hemodynamic response with fNIRS in pediatric TBI patients. A trend of  reduced prefrontal hemodynamic response in patients in the acute phase after injury  was found suggesting impairment in cognitive performance that warrants further  study.<p /> <p>Language: en</p>",
language="en",
issn="1090-3798",
doi="10.1016/j.ejpn.2020.12.008",
url="http://dx.doi.org/10.1016/j.ejpn.2020.12.008"
}