@article{ref1,
title="Response inhibition deficits in women with the FMR1 premutation are associated with age and fall risk",
journal="Brain and cognition",
year="2020",
author="Moser, Carly and Schmitt, Lyndsay and Schmidt, Joseph and Fairchild, Amanda and Klusek, Jessica",
volume="148",
number="",
pages="e105675-e105675",
abstract="One in 113-178 females worldwide carry a premutation allele on the FMR1 gene. The FMR1 premutation is linked to neurocognitive and neuromotor impairments, although  the phenotype is not fully understood, particularly with respect to age effects. This study sought to define oculomotor response inhibition skills in women with the  FMR1 premutation and their association with age and fall risk. We employed an  antisaccade eye-tracking paradigm to index oculomotor inhibition skills in 35 women  with the FMR1 premutation and 28 control women. The FMR1 premutation group exhibited  longer antisaccade latency and reduced accuracy relative to controls, indicating  deficient response inhibition skills. Longer response latency was associated with  older age in the FMR1 premutation and was also predictive of fall risk. <br><br>FINDINGS  highlight the utility of the antisaccade paradigm for detecting early signs of  age-related executive decline in the FMR1 premutation, which is related to fall  risk. <br><br>FINDINGS support the need for clinical prevention efforts to decrease and  delay the trajectory of age-related executive decline in women with the FMR1  premutation during midlife.<p /> <p>Language: en</p>",
language="en",
issn="0278-2626",
doi="10.1016/j.bandc.2020.105675",
url="http://dx.doi.org/10.1016/j.bandc.2020.105675"
}