@article{ref1,
title="Working memory associated with anti-suicidal ideation effect of repeated-dose intravenous ketamine in depressed patients",
journal="European archives of psychiatry and clinical neuroscience",
year="2021",
author="Chen, Xiaoyu and Wang, Mingqia and Hu, Yiru and Zhan, Yanni and Zhou, Yanling and Zheng, Wei and Liu, Weijian and Wang, Chengyu and Zhong, Xiaomei and Li, Hanqiu and Lan, Xiaofeng and Ning, Yuping and Zhang, Bin",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Suicide is a tremendous threat to global public health, and a large number of people who committed suicide suffered the pain of mental diseases, especially major  depressive disorder (MDD). Previous study showed that ketamine could reduce suicidal  ideation (SI), potentially by improving the impaired working memory (WM). The  objective of current study was to illuminate the relationship between WM and SI in  MDD with repeated ketamine treatment. MDD patients with SI (n = 59) and without SI  (n = 37) completed six intravenous infusions of ketamine (0.5 mg/kg over 40 min)  over 12 days (Day 1, 3, 5, 8, 10 and 12). The severity of depressive symptoms, SI  and WM were assessed at baseline, day 13 and day 26. We found that WM was  significantly improved after 6 ketamine infusions (F = 161.284, p = 0.009) in a  linear mixed model. Correlation analysis showed that the improvement of depressive  symptom was significantly associated with WM at baseline (r =  - 0.265, p = 0.042)  and the reduction in SSI-part I was related to the change of WM (r = 0.276,  p = 0.034) in the MDD patients with SI. Furthermore, Logistic regression analysis  showed that improvement in WM might predict the anti-SI response of ketamine. Our  findings suggest that the improvement of working memory may partly account for the  anti-SI effect of ketamine, and intervention of improving working memory function  may be capable of reducing suicidal ideation.<p /> <p>Language: en</p>",
language="en",
issn="0940-1334",
doi="10.1007/s00406-020-01221-z",
url="http://dx.doi.org/10.1007/s00406-020-01221-z"
}