@article{ref1,
title="Association of prior concussion with hippocampal volume and symptoms in collegiate-aged athletes",
journal="Journal of neurotrauma",
year="2021",
author="Meier, Timothy and Brett, Benjamin L. and Mayer, Andrew and Nelson, Lindsay D. and Nader, Amy M. and Kirk, Alexander and Espana, Lezlie and Powell, Jennifer",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="There is concern that prior concussion and contact sport exposure may have negative effects on brain structure and function. Accurately quantifying prior concussion is  complicated by the fact that multiple definitions exist, with recent definitions  allowing for diagnosis based on the presence of symptoms alone (Concussion in Sport  Group criteria; CISG) rather than the presence of acute injury characteristics such  as alterations in mental status (American Congress of Rehabilitation Medicine  criteria; ACRM). The goals of the current work were to determine the effects of  prior concussion and contact sport exposure on gray matter structure and clinical  measures in healthy, young-adult athletes and to determine the extent to which these  associations are influenced by diagnostic criteria used to retrospectively quantify  concussions. One-hundred and eight collegiate-aged athletes were enrolled; 106  athletes were included in final analyses (age 21.37±1.69; 33 female). Participants  completed a clinical battery of self-report and neurocognitive measures and MRI to  quantify subcortical volumes and cortical thickness. Semi-structured interviews were  conducted to measure exposure to contact sports and the number of prior concussions  based on CISG and ACRM criteria. There was a significant association of  concussion-related and psychological symptoms with prior concussions based on ACRM  (ps<0.05) but not CISG criteria. Hippocampal volume was inversely associated with  the number of prior concussions for both criteria (ps<0.05). <br><br>FINDINGS provide  evidence that prior concussions are associated with smaller hippocampal volumes and  greater subjective clinical symptoms in otherwise healthy athletes and highlight the  importance of diagnostic criteria used to quantify prior concussion.<p /> <p>Language: en</p>",
language="en",
issn="0897-7151",
doi="10.1089/neu.2020.7143",
url="http://dx.doi.org/10.1089/neu.2020.7143"
}