@article{ref1,
title="Global DNA methylation in suicidal ideation and suicide attempt in schizophrenia",
journal="Psychiatric genetics",
year="2020",
author="De Luca, Vincenzo and Nobrega, José N. and Graff, Ariel and Raymond, Roger and Bani-Fatemi, Ali and Gerretsen, Philip and Dai, Nasia and Adanty, Christopher",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Suicidal behavior is influenced by many risk factors such as childhood trauma, stressful life events, genetic factors, and severe mental illnesses. Suicidal  ideation is present in 50% of schizophrenia patients and is associated with an  elevated risk of suicide attempt. Studies have shown that epigenetic mechanisms are  associated with suicidal behavior in schizophrenia. Although several studies have  suggested the importance of epigenetic factors in suicidal ideation and behavior, no  studies have investigated global methylation in association with these two  phenotypes. This study investigated global methylation level/change in association  with current and emergent suicidal ideation and also with suicide attempt. Forty-seven schizophrenia patients were assessed for the association between global  methylation and suicide attempt, and a subsample of these patients (n = 27) was  assessed for current suicidal ideation. Afterwards, we performed a longitudinal  analysis in which global methylation changes during a 3-month follow-up were  compared between patients with and without emergent suicidal ideation. This  methylation analysis did not find evidence for a significant association between  global methylation and suicidal ideation or suicide attempt. To date, there are no  robust biomarkers predicting suicidal ideation or behavior in psychotic patients. This study is the first to investigate global methylation in predicting suicidal  ideation and behavior. Although we did not find evidence for an association between  global methylation and these phenotypes, our findings may offer novel insights into  the molecular mechanisms linked to suicide. Future investigation may measure global  methylation in association with suicidal ideation or behavior in larger samples.<p /> <p>Language: en</p>",
language="en",
issn="0955-8829",
doi="10.1097/YPG.0000000000000273",
url="http://dx.doi.org/10.1097/YPG.0000000000000273"
}