@article{ref1,
title="Candidate pharmacological treatments for substance use disorder and suicide identified by gene co-expression network-based drug repositioning",
journal="American journal of medical genetics. part B, neuropsychiatric genetics",
year="2021",
author="Fresno, Cristobal and Genis-Mendoza, Alma Delia and Monroy-Jaramillo, Nancy and Martinez-Magaña, Jose Jaime and Cabrera-Mendoza, Brenda and Nicolini, Humberto and Vázquez-Roque, Rubén Antonio and Flores, Gonzalo and Díaz-Otañez, Carlos Enrique and Garcia-Dolores, Fernando and López Armenta, Mauro and Walss-Bass, Consuelo and Fries, Gabriel Rodrigo",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Patients with substance use disorders (SUD) are at high risk to die by suicide. So far, the neurobiology of the suicide-SUD association has not been elucidated. This  study aimed to identify potential pharmacological targets among hub genes from brain  gene co-expression networks of individuals with SUD in a suicidal and non-suicidal  context. Post-mortem samples from the prefrontal cortex of 79 individuals were  analyzed. Individuals were classified into the following groups: suicides with SUD  (n = 28), suicides without SUD (n = 23), nonsuicides with SUD (n = 9), nonsuicides  without SUD (n = 19). Gene expression profiles were evaluated with the Illumina  HumanHT-12 v4 array. Co-expression networks were constructed in WGCNA using the  differentially expressed genes found in the comparisons: (a) suicides with and  without SUD and (b) nonsuicides with and without SUD. Hub genes were selected for  drug-gene interaction testing in the DGIdb database. Among drugs interacting with  hub genes in suicides we found MAOA inhibitors and dextromethorphan. In the  nonsuicide individuals, we found interactions with eglumegad and antipsychotics  (olanzapine, clozapine, loxapine). Modafinil was found to interact with genes in  both suicides and nonsuicides. These drugs represent possible candidate treatments  for patients with SUD with and without suicidal behavior and their study in each  context is encouraged.<p /> <p>Language: en</p>",
language="en",
issn="1552-4841",
doi="10.1002/ajmg.b.32830",
url="http://dx.doi.org/10.1002/ajmg.b.32830"
}