@article{ref1,
title="Effects of an allostatic closed-loop neurotechnology (HIRREM) on brain functional connectivity laterality in military-related traumatic stress",
journal="Journal of neuroimaging",
year="2021",
author="Simpson, Sean L. and Gerdes, Lee and Lee, Sung W. and Tegeler, Catherine L. and Laurienti, Paul J. and Morgan, Ashley R. and Tegeler, Charles H. and Dagenbach, Dale E.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND AND PURPOSE: Brain asymmetries are reported in posttraumatic stress disorder, but many aspects of laterality and traumatic stress remain underexplored. This study explores lateralization changes in resting state brain network functional  connectivity in a cohort with symptoms of military-related traumatic stress,  associated with use of a closed-loop neurotechnology, HIRREM. <br><br>METHODS: Eighteen  participants (17 males, mean age 41 years [SD = 7]) received 19.5 (1.1) HIRREM  sessions over 12 days. Whole brain resting magnetic resonance imaging was done pre-  and post-HIRREM. Laterality of functional connectivity was assessed on a whole brain  basis, and in six predefined networks or regions. Laterality of connectivity within  networks or regions was assessed separately from laterality of connections between  networks or regions. <br><br>RESULTS: Before HIRREM, significant laterality effects of  connection type (ipsilateral for either side, or contralateral in either direction)  were observed for the whole brain, within networks or regions, and between networks  or regions. Post-HIRREM, there were significant changes for within-network or  within-region analysis in the motor network, and changes for between-network or  between-region analyses for the salience network and the motor cortex. <br><br>CONCLUSIONS:  Among military service members and Veterans with symptoms of traumatic stress,  asymmetries of network and brain region connectivity patterns were identified prior  to usage of HIRREM. A variety of changes in lateralized patterns of brain  connectivity were identified postintervention. These laterality findings may inform  future studies of brain connectivity in traumatic stress disorders, with potential  to point to mechanisms of action for successful intervention.<p /> <p>Language: en</p>",
language="en",
issn="1051-2284",
doi="10.1111/jon.12825",
url="http://dx.doi.org/10.1111/jon.12825"
}