@article{ref1,
title="Association between childhood adversities and psychopathology onset throughout the lifespan: findings from a large metropolitan population",
journal="Journal of psychiatric research",
year="2020",
author="Santana, Geilson Lima and Andrade, Laura Helena and Coêlho, Bruno Mendonça and Wang, Yuan-Pang and Viana, Maria Carmen",
volume="135",
number="",
pages="8-14",
abstract="BACKGROUND: Childhood adversities (ECA) are deleterious experiences that can occur during individuals' development, which has been associated with several negative  health outcomes. <br><br>AIM: Analyze the effect of ECA on the onset of DSM-IV disorders  throughout life. <br><br>METHOD: The Composite International Diagnostic Interview (CIDI) was  used in a stratified, multistage area probability sample of 5037 individuals aged 18  or more to assess the presence of childhood adversities, 20 psychiatric disorders  and their ages of onset. Discrete-time survival models were performed to estimate  the odds of disorder onset. Data are from the São Paulo Megacity Mental Health  Survey, the Brazilian branch of the World Mental Health Survey Initiative. <br><br>FINDINGS:  53.6% of the sample experienced at least one ECA, and parental death (16.1%) and  physical abuse (16%) were the most reported occurrences. Parental mental illness  (OR = 1.99 to 2.27) and family violence (OR = 1.55 to 1.99) were the adversities  most consistently associated with psychopathology across all age groups, while  economic adversities (OR = 2.71 to 3.30) and parent criminality (OR = 1.72 to 1.77)  were associated with psychopathology in individuals whose onset of disorder occurred  from age 13 years on. Parental mental disorders and economic adversities were the  strongest and most consistent predictors of all four classes of psychopathologies  examined in multivariate models controlled for the clustering of adversities. Physical abuse was associated with externalizing disorders, while sexual abuse with  internalizing disorders. <br><br>INTERPRETATION: Childhood adversities were consistently  associated with mental disorders. Economic adversities and parent mental disorders  were predictive of psychopathology even if controlled for type (additive) and type  and number of adversities (interactive models). Parental mental disorder and family  violence were the main predictors of psychopathology onset across all age groups. Parental mental disorder was the only adversity that predicted all classes of  disorders investigated.<p /> <p>Language: en</p>",
language="en",
issn="0022-3956",
doi="10.1016/j.jpsychires.2020.12.046",
url="http://dx.doi.org/10.1016/j.jpsychires.2020.12.046"
}