@article{ref1,
title="Single prolonged stress blocks sleep homeostasis and pre-trauma sleep deprivation does not exacerbate the severity of trauma-induced fear-associated memory  impairments",
journal="PLoS one",
year="2021",
author="Gerstner, Jason R. and Davis, Christopher J. and Vanderheyden, William M.",
volume="16",
number="1",
pages="e0243743-e0243743",
abstract="Sleep is intimately linked to cognitive performance and exposure to traumatic stress that leads to post-traumatic stress disorder (PTSD) impairs both sleep and cognitive  function. However, the contribution of pre-trauma sleep loss to subsequent  trauma-dependent fear-associated memory impairment remains unstudied. We  hypothesized that sleep deprivation (SD) prior to trauma exposure may increase the  severity of a PTSD-like phenotype in rats exposed to single prolonged stress (SPS),  a rodent model of PTSD. Rats were exposed to SPS alone, SD alone, or a combination  of SPS+SD and measures of fear-associated memory impairments and vigilance state  changes were compared to a group of control animals not exposed to SPS or SD. We  found that SPS, and SPS+SD animals showed impaired fear-associated memory processing  and that the addition of SD to SPS did not further exaggerate the effect of SPS  alone. Additionally, the combination of SPS with SD results in a unique homeostatic  sleep duration phenotype when compared to SD, SPS, or control animals. SPS exposure  following SD represses homeostatic rebound and eliminates sleep-deprivation-induced  increases in NREM sleep delta power. This work identifies a unique time frame where  trauma exposure and sleep interact and identifies this window of time as a potential  therapeutic treatment window for staving off the negative consequences of trauma  exposure.<p /> <p>Language: en</p>",
language="en",
issn="1932-6203",
doi="10.1371/journal.pone.0243743",
url="http://dx.doi.org/10.1371/journal.pone.0243743"
}