@article{ref1,
title="Coordinating global multi-site studies of military-relevant traumatic brain injury: opportunities, challenges, and harmonization guidelines",
journal="Brain imaging and behavior",
year="2021",
author="Wilde, Elisabeth A. and Thompson, Paul M. and Zafonte, Ross and Bigler, Erin D. and Belanger, Heather G. and Velez, Carmen and Irimia, Andrei and Hovenden, Elizabeth S. and Hodges, Cooper B. and Hinds, Sidney R. 2nd and Hayes, Jasmeet P. and Wang, Xin and Wade, Benjamin Sc and Troyanskaya, Maya and Taylor, Brian A. and Levin, Harvey S. and Kremen, William S. and Koerte, Inga K. and Kenney, Kimbra and Adamson, Maheen M. and Adams, John T. and Dennis, Emily L. and Tate, David F. and Ware, Ashley L. and Clark, Alexandra L. and Bouchard, Heather C. and Sullivan, Danielle R. and Shenton, Martha E. and Scheibel, Randall S. and Pugh, Mary Jo and Ollinger, John and Newsome, Mary R. and Morey, Rajendra A. and Han, Kihwan and Goodrich-Hunsaker, Naomi J. and Geuze, Elbert and Franz, Carol E. and Eapen, Blessen C. and Disner, Seth G. and Delano-Wood, Lisa M. and Lindsey, Hannah M.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Traumatic brain injury (TBI) is common among military personnel and the civilian population and is often followed by a heterogeneous array of clinical, cognitive,  behavioral, mood, and neuroimaging changes. Unlike many neurological disorders that  have a characteristic abnormal central neurologic area(s) of abnormality  pathognomonic to the disorder, a sufficient head impact may cause focal, multifocal,  diffuse or combination of injury to the brain. This inconsistent presentation makes  it difficult to establish or validate biological and imaging markers that could help  improve diagnostic and prognostic accuracy in this patient population. The purpose  of this manuscript is to describe both the challenges and opportunities when  conducting military-relevant TBI research and introduce the Enhancing NeuroImaging  Genetics through Meta-Analysis (ENIGMA) Military Brain Injury working group. ENIGMA  is a worldwide consortium focused on improving replicability and analytical power  through data sharing and collaboration. In this paper, we discuss challenges  affecting efforts to aggregate data in this patient group. In addition, we highlight  how &quot;big data&quot; approaches might be used to understand better the role that each of  these variables might play in the imaging and functional phenotypes of TBI in  Service member and Veteran populations, and how data may be used to examine  important military specific issues such as return to duty, the late effects of  combat-related injury, and alteration of the natural aging processes.<p /> <p>Language: en</p>",
language="en",
issn="1931-7557",
doi="10.1007/s11682-020-00423-2",
url="http://dx.doi.org/10.1007/s11682-020-00423-2"
}