@article{ref1,
title="Tractography-pathology correlations in traumatic brain injury: a TRACK-TBI Study",
journal="Journal of neurotrauma",
year="2021",
author="Nolan, Amber L. and Iacono, Diego and Petersen, Cathrine and Stevens, Allison and Jain, Sonia and van der Kouwe, Andre and Edlow, Brian L. and Wang, Ruopeng and Diamond, Bram and Diaz-Arrastia, Ramon and Keene, C. Dirk and Manley, Geoffrey T. and Perl, Daniel and Fischl, Bruce and Mukherjee, Pratik and Mac Donald, Christine L. and Markowitz, Amy J.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Diffusion tractography MRI can infer changes in network connectivity in patients with traumatic brain injury (TBI), but the pathological substrates of disconnected  tracts have not been well-defined due to a lack of high-resolution imaging with  histopathological validation. We developed an ex vivo MRI protocol to analyze tract  terminations at 750 μm isotropic resolution, followed by histopathologic evaluation  of white matter pathology, and applied these methods to a 60-year-old man who died  26 days after TBI. Analysis of 74 cerebral hemispheric white matter regions revealed  a heterogeneous distribution of tract disruptions. Associated histopathology  identified variable white matter injury with patchy deposition of amyloid precursor  protein and loss of neurofilament-positive axonal processes, myelin dissolution,  astrogliosis, microgliosis, and perivascular hemosiderin-laden macrophages. Multiple  linear regression revealed that tract disruption strongly correlated with the  density of amyloid precursor protein (APP)-positive axonal swellings and  neurofilament loss. Ex vivo diffusion MRI can detect tract disruptions in the human  brain that reflect axonal injury.<p /> <p>Language: en</p>",
language="en",
issn="0897-7151",
doi="10.1089/neu.2020.7373",
url="http://dx.doi.org/10.1089/neu.2020.7373"
}