@article{ref1,
title="DNA methylation signatures of aggression and closely related constructs: a meta-analysis of epigenome-wide studies across the lifespan",
journal="Molecular psychiatry",
year="2021",
author="Räikkönen, Katri and Konrad, Kerstin and Mishra, Pashupati Prasad and Wang, Yunzhang and Corcoran, David L. and Colins, Olivier F. and Vafeiadi, Marina and Evandt, Jorunn and Gutzkow, Kristine B. and Binder, Elisabeth and Czamara, Darina and Freitag, Christine M. and Franke, Barbara and Kluft, Cornelis and Ligthart, Lannie and van der Meer, Dennis and Campbell, Archie and Bakermans-Kranenburg, Marian J. and Felix, Janine F. and Vuoksimaa, Eero and Korhonen, Tellervo and Boomsma, Dorret I. and Grazuleviciene, Regina and Gonzalez, Juan R. and Klein, Marieke and Sebert, Sylvain and Vrijheid, Martine and Fernández-Rivas, Aranzazu and Hervás, Amaia and Sirignano, Lea and Streit, Fabian and Lowry, Estelle and Bartels, Meike and Parmar, Priyanka and Baselmans, Bart M. L. and Jansen, Rick and Ip, Hill F. and Meijer, Mandy and Jan Bonder, Marc and Alemany, Silvia and Escaramis, Georgia and Strandberg, Timo and Vermeiren, Robert and Lehtimäki, Terho and Raitakari, Olli and Vetró, Agnes and Send, Tabea S. and Relton, Caroline and McIntosh, Andrew M. and Evans, Kathryn L. and Sunyer, Jordi and Hägg, Sara and Pedersen, Nancy L. and Deuschle, Michael and Witt, Stephanie H. and Snieder, Harold and Jylhävä, Juulia and Frank, Josef and Corpeleijn, Eva and Chiocchetti, Andreas G. and Sugden, Karen and Roetman, Peter J. and Suderman, Matthew and Hagenbeek, Fiona A. and van Dongen, Jenny and Arseneault, Louise and Hannon, Eilis and Mill, Jonathan and Poulton, Richie and van Ijzendoorn, Marinus H. and Tiemeier, Henning and Moffitt, Terrie E. and Ollikainen, Miina and Kaprio, Jaakko and Franke, Lude and Morris, Stewart W. and Walker, Rosie M. and Adams, Mark J. and Hafferty, Jonathan D. and Mulder, Rosa H. and Ismail, Khadeeja and Caspi, Avshalom and Järvelin, Marjo-Riitta and Keltikangas-Järvinen, Liisa and Hakulinen, Christian and Davies, Gareth E. and Küpers, Leanne K. and Lahti, Jari",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with  aggression. Here, we report the first large meta-analysis of epigenome-wide  association studies (EWAS) of aggressive behavior (N = 15,324 participants). In  peripheral blood samples of 14,434 participants from 18 cohorts with mean ages  ranging from 7 to 68 years, 13 methylation sites were significantly associated with  aggression (alpha = 1.2 × 10(-7); Bonferroni correction). In cord blood samples of  2425 children from five cohorts with aggression assessed at mean ages ranging from 4  to 7 years, 83% of these sites showed the same direction of association with  childhood aggression (r = 0.74, p = 0.006) but no epigenome-wide significant sites  were found. Top-sites (48 at a false discovery rate of 5% in the peripheral blood  meta-analysis or in a combined meta-analysis of peripheral blood and cord blood)  have been associated with chemical exposures, smoking, cognition, metabolic traits,  and genetic variation (mQTLs). Three genes whose expression levels were associated  with top-sites were previously linked to schizophrenia and general risk tolerance. At six CpGs, DNA methylation variation in blood mirrors variation in the brain. On  average 44% (range = 3-82%) of the aggression-methylation association was explained  by current and former smoking and BMI. These findings point at loci that are  sensitive to chemical exposures with potential implications for neuronal functions. We hope these results to be a starting point for studies leading to applications as  peripheral biomarkers and to reveal causal relationships with aggression and related  traits.<p /> <p>Language: en</p>",
language="en",
issn="1359-4184",
doi="10.1038/s41380-020-00987-x",
url="http://dx.doi.org/10.1038/s41380-020-00987-x"
}