@article{ref1,
title="Modeling endophenotypes of suicidal behavior in animals",
journal="Neuroscience and biobehavioral reviews",
year="2021",
author="Dwivedi, Yogesh and Roy, Bhaskar",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Suicide is a major public health concern. One of the common contributors to the increased risk for suicide is the genetic constitution of individuals, which  determines certain endophenotypic traits used as quantifiable measure of  neurobiological functions. Therefore, a logical deconstruction of the originating  endophenotypes associated with suicidal risk could provide a better understanding of  this complex disorder. In this regard, non-human animals can be a useful resource to  test endophenotypes of suicidal behavior and the neurobiology underlying these  endophenotypes. In this review, we have focused on the neurobiological  abnormalities, primarily genetic and epigenetic abnormalities, associated with  suicidal behavior and the scope of their modeling in animals. This can substantially  advance the current understanding of suicidal behavior manifested with certain  trait-based endophenotypes and may provide an opportunity to test novel hypotheses  as well as aid in the development of treatment opportunities and risk assessment.<p /> <p>Language: en</p>",
language="en",
issn="0149-7634",
doi="10.1016/j.neubiorev.2020.12.033",
url="http://dx.doi.org/10.1016/j.neubiorev.2020.12.033"
}