@article{ref1,
title="The manifestation of individual differences in sensitivity to punishment during resting state is modulated by eye state",
journal="Cognitive, affective and behavioral neuroscience",
year="2021",
author="Palomar-García, María-Ángeles and Miró-Padilla, Anna and Bueichekú, Elisenda and Adrián-Ventura, Jesús and Costumero, Víctor and Aguirre, Naiara and Villar-Rodríguez, Esteban and Marin-Marin, Lidón and Ávila, César and Barrós-Loscertales, Alfonso",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Structural and functional neuroimaging studies have shown that brain areas associated with fear and anxiety (defensive system areas) are modulated by  individual differences in sensitivity to punishment (SP). However, little is known  about how SP is related to brain functional connectivity and the factors that  modulate this relationship. In this study, we investigated whether a simple  methodological manipulation, such as performing a resting state with eyes open or  eyes closed, can modulate the manifestation of individual differences in SP. To this  end, we performed an exploratory fMRI resting state study in which a group of  participants (n = 88) performed a resting state with eyes closed and another group  (n = 56) performed a resting state with eyes open. All participants completed the  Sensitivity to Punishment and Sensitivity to Reward Questionnaire. Seed-based  functional connectivity analyses were performed in the amygdala, hippocampus, and  periaqueductal gray (PAG). Our results showed that the relationship between SP and  left amygdala-precuneus and left hippocampus-precuneus functional connectivity was  modulated by eye state. Moreover, in the eyes open group, SP was negatively related  to the functional connectivity between the PAG and amygdala and between the PAG and  left hippocampus, and it was positively related to the functional connectivity  between the amygdala and hippocampus. Together, our results may suggest underlying  differences in the connectivity between anxiety-related areas based on eye state,  which in turn would affect the manifestation of individual differences in SP.<p /> <p>Language: en</p>",
language="en",
issn="1530-7026",
doi="10.3758/s13415-020-00856-8",
url="http://dx.doi.org/10.3758/s13415-020-00856-8"
}