@article{ref1,
title="Cerebral blood flow predicts recovery in children with persistent post-concussion symptoms following mild traumatic brain injury",
journal="Journal of neurotrauma",
year="2021",
author="Scurfield, Alex and Yan, Tingting and Wang, Yang and Carlson, Helen L. and Iyer, Kartik and Barlow, Karen Maria",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Persistent post-concussion symptoms (PPCS) following pediatric mild traumatic brain injury (mTBI) are associated with differential changes in cerebral blood flow (CBF). Given its potential as a therapeutic target, we examined CBF changes during recovery  in children with PPCS. We hypothesized that CBF would decrease and that such  decreases would mirror clinical recovery. In a prospective cohort study, 61 children  (mean age 14 (SD=2.6) years; 41% male) with PPCS were imaged with 3D  pseudo-continuous arterial spin-labelled (pCASL) MRI at 4-6 and 8-10 weeks  post-injury. Exclusion criteria included any significant past medical history and/or  previous concussion within three months. 23 participants had clinically recovered at  the time of the second scan. We found that relative and mean absolute CBF were  higher in participants with poor recovery, 44.0 (95%CI: 43.32, 44.67) compared to  those with good recovery, 42.19 (95%CI: 41.77, 42.60) ml/min/100g grey tissue and  decreased over time (Beta=-1.75; p<.001). The decrease was greater in those with  good recovery (Beta=2.29; p<.001) and predicted outcome in 77% of children with PPCS  (OR.54, 95%CI:.36,.80; p=.002). Future studies are warranted to validate the  utility of CBF as a useful predictive biomarker of outcome in PPCS.<p /> <p>Language: en</p>",
language="en",
issn="0897-7151",
doi="10.1089/neu.2020.7566",
url="http://dx.doi.org/10.1089/neu.2020.7566"
}