@article{ref1,
title="The management of pediatric severe traumatic brain injury: Italian guideline",
journal="Minerva anestesiologica",
year="2021",
author="Mangiantini, Francesca and Agostiniani, Rino and Melosi, Francesca and Falsaperla, Raffaele and Lubrano, Riccardo and Lucenteforte, Ersilia and Falconi, Martina and Bussolin, Leonardo and De Masi, Salvatore and Parri, Niccolò and Leo, Maria C. and Bettiol, Alessandra and Grandoni, Manuela and Spacca, Barbara and Cecchi, Costanza and Rosati, Anna and Petrini, Flavia and Conti, Giorgio and De Luca, Marco and Mancino, Aldo and Calderini, Edoardo and Talamonti, Giuseppe",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="INTRODUCTION: The aim of the work is to update the &quot;Guidelines for the Management of Severe Traumatic Brain Injury&quot; published in 2012, to reflect the new available  evidence, and develop the Italian national guideline for the management of severe  pediatric head injuries to reduce variation in practice and ensure optimal care to  patients. EVIDENCE ACQUISITION: MEDLINE and EMBASE were searched from January 2009  to October 2017. Inclusion criteria were: English language, pediatric populations  (0-18 years) or mixed populations (pediatric-adult) with available age subgroup  analyses. The guideline development process was started by the Promoting Group that  composed a multidisciplinary panel of experts, with the representatives of the  Scientific Societies, the independent expert specialists and a representative of the  Patient Associations. The panel selected the clinical questions, discussed the  evidences and formulated the text of the recommendations. The documentarists of the  University of Florence oversaw the bibliographic research strategy. A group of  literature reviewers evaluated the selected literature and compiled the table of  evidence for each clinical question. EVIDENCE SYNTHESIS: The search strategies  identified 4254 articles. We selected 3227 abstract (first screening) and, finally  included 67 articles (second screening) to update the guideline. This Italian update  includes 25 evidence-based recommendations and 5 research recommendations. <br><br>CONCLUSIONS: In recent years, progress has been made on the understanding of severe  pediatric brain injury, as well as on that concerning all major traumatic pathology. This has led to a progressive improvement in the clinical outcome, although the  quantity and quality of evidence remains particularly low.<p /> <p>Language: en</p>",
language="en",
issn="0375-9393",
doi="10.23736/S0375-9393.20.14122-1",
url="http://dx.doi.org/10.23736/S0375-9393.20.14122-1"
}