@article{ref1,
title="Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality",
journal="Translational psychiatry",
year="2021",
author="Levey, Daniel F. and Polimanti, Renato and Ursano, Robert J. and Nuñez, Yaira Z. and Wendt, Frank R. and Pathak, Gita A. and Kessler, Ronald C. and Kranzler, Henry R. and Stein, Murray B. and Gelernter, Joel",
volume="11",
number="1",
pages="e34-e34",
abstract="Substance dependence diagnoses (SDs) are important risk factors for suicidality. We investigated the associations of multiple SDs with different suicidality outcomes,  testing how genetic background moderates these associations. The Yale-Penn cohort  (N = 15,557) was recruited to investigate the genetics of SDs. The Army STARRS  (Study to Assess Risk and Resilience in Servicemembers) cohort (N = 11,236) was  recruited to evaluate mental health risk and resilience among Army personnel. We  applied multivariate logistic regression to investigate the associations of SDs with  suicidality and, in the Yale-Penn cohort, we used the structured linear mixed model  (StructLMM) to study multivariate gene-environment interactions. In Yale-Penn,  lifetime polysubstance dependence was strongly associated with lifetime suicidality:  having five SDs showed an association with suicidality, from odds ratio (OR) = 6.77  (95% confidence interval, CI = 5.74-7.99) for suicidal ideation (SI) to OR = 3.61  (95% CI = 2.7-4.86) for suicide attempt (SA). In Army STARRS, having multiple  substance use disorders for alcohol and/or drugs was associated with increased  suicidality ranging from OR = 2.88 (95% CI = 2.6-3.19) for SI to OR = 3.92 (95%  CI = 3.19-4.81) for SA. In Yale-Penn, we identified multivariate gene-environment  interactions (Bayes factors, BF > 0) of SI with respect to a gene cluster on  chromosome 16 (LCAT, p = 1.82 × 10(-7); TSNAXIP1, p = 2.13 × 10(-7); CENPT,  p = 2.32 × 10(-7); PARD6A, p = 5.57 × 10(-7)) for opioid dependence (BF = 12.2),  cocaine dependence (BF = 12.1), nicotine dependence (BF = 9.2), and polysubstance  dependence (BF = 2.1). Comorbidity of multiple SDs is a significant associated with  suicidality and heritability of suicidality is partially moderated by multivariate  gene interactions.<p /> <p>Language: en</p>",
language="en",
issn="2158-3188",
doi="10.1038/s41398-020-01153-1",
url="http://dx.doi.org/10.1038/s41398-020-01153-1"
}