@article{ref1,
title="Childhood Trauma increases suicidal behaviour in a treatment-resistant depression population: a FACE-DR report",
journal="Journal of psychiatric research",
year="2020",
author="Stephan, Florian and Camus, Vincent and Bougerol, Thierry and Schmitt, Laurent and Samalin, Ludovic and Richieri, Raphaëlle and Petrucci, Jean and Molière, Fanny and Bennabi, Djamila and Bellivier, Frank and Amato, Thierry D. and Walter, Michel and Vaiva, Guillaume and Yrondi, Antoine and Moirand, Remi and Maruani, Julia and Horn, Mathilde and Holtzmann, Jérôme and Haffen, Emmanuel and Genty, Jean-Baptiste and Doumy, Olivier and Llorca, Pierre-Michel and Leboyer, Marion and Lançon, Christophe",
volume="135",
number="",
pages="20-27",
abstract="OBJECTIVE: In addition to heredity, exposure to early-life adversity is an important predisposing risk factor of suicidal behaviour. Although the association between  Childhood Trauma (CT) and suicide risk is well documented, interactions between CT  and suicidal behaviour in Treatment-Resistant Depression (TRD) populations have  received little coverage. This study aimed to evaluate i) association between CT and  suicidal behaviour in a TRD population, and ii) the role of personality traits and  impulsiveness as potential factors of mediation in these associations. <br><br>METHODS:  Patients were recruited from a cohort of the French network of TRD expert centers. Depressive symptom severity, CT, suicidal behaviour, personality traits, and  impulsiveness were assessed with the Montgomery-Åsberg Depression Rating Scale  (MADRS), the Childhood Trauma Questionnaire (CTQ), the Columbia Suicide Severity  Rating Scale (CSSRS), the Structured Clinical Interview for DSM-IV, the Big Five  Inventory, and the Barratt Impulsivness Scale (BIS) respectively. <br><br>RESULTS: Among the  256 patients with a baseline CTQ, in relation to suicide risk for the current  depressive episode, we found an association with the total CTQ scores mediated by  the intensity of the current episode in a model adjusted for age and sex (total  effect: β = 0.171; p = 0.011, direct effect: β = 0.135; p = 0.043; indirect effect:  β = 0.036; p = 0.048). Focusing on CT subtypes, we detected an association between  suicide risk and physical neglect in a model adjusted for age and sex (β = 0.301;  p = 0.002), without any mediation by the intensity of the current episode. There was  no mediation effect from personality traits nor impulsiveness. With regards to CSSRS  to assess suicidal ideation, we did not find any association with the total CTQ  score and CT subtype scores. <br><br>CONCLUSION: We report a strong association between  suicidal behaviour and CT (in particular childhood physical neglect) in a TRD  population.<p /> <p>Language: en</p>",
language="en",
issn="0022-3956",
doi="10.1016/j.jpsychires.2020.12.055",
url="http://dx.doi.org/10.1016/j.jpsychires.2020.12.055"
}