@article{ref1,
title="Mobility performance impacts mortality risk in community-dwelling healthy older adults in Japan: a prospective observational study",
journal="Aging clinical and experimental research",
year="2021",
author="Otsuka, Hiromasa and Kobayashi, Hiroki and Suzuki, Kiyozumi and Hayashi, Yuta and Ikeda, Jin and Kushimoto, Masaru and Hara, Motohiko and Abe, Masanori and Kato, Kimitoshi and Soma, Masayoshi",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND: The timed up and go (TUG) test assesses balance and mobility performance. <br><br>AIM: This study aims to investigate the association between TUG time and mortality in Japanese older persons and to clarify possible moderation effects on mortality and TUG time. <br><br>METHODS: In all, 874 participants who were ≥ 65 years of age completed the TUG test and had their anthropometric parameters and physical functions measured. We investigated the association between all-cause mortality and TUG using a Cox regression model that included confounders, and explored the time associated with mortality using a restricted cubic spline. We also performed subgroup analyses to explore whether age, sex, and body mass index (BMI) affected the relationship between TUG time and mortality. <br><br>RESULTS: The median age and mean follow-up period were 74 and 8.5 years, respectively. Median TUG time was 7.4 s and the prevalence of mortality was 25.7%. TUG time in one second was positively associated with an increased risk of total mortality [hazard ratio (HR): 1.054 (1.016-1.093); P = 0.005] in the Cox regression model. The positive association of mortality and TUG time was present when the TUG was over 10.5 s in the restricted cubic spline curve. Older age (75 years or older) moderated the relationship between TUG time and mortality [P(interaction) = 0.096]. <br><br>CONCLUSION: This study demonstrates that TUG time is associated with all-cause mortality in Japanese older adults.<p /> <p>Language: en</p>",
language="en",
issn="1594-0667",
doi="10.1007/s40520-021-01787-1",
url="http://dx.doi.org/10.1007/s40520-021-01787-1"
}