@article{ref1,
title="Ability of S100B to predict post-concussion syndrome in paediatric patients who present to the emergency department with mild traumatic brain injury",
journal="British journal of neurosurgery",
year="2021",
author="Kelmendi, Fatos M. and Morina, Arsim A. and Mekaj, Agon Y. and Dragusha, Shefki and Ahmeti, Feti and Alimehmeti, Ridvan and Morina, Qamile and Berisha, Murat and Krasniqi, Blerim and Kerolli, Berat",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="INTRODUCTION: Among children who sustain mild traumatic brain injury (mTBI), 10-30% develop a cluster of cognitive, physical, and emotional symptoms commonly referred to as post-concussion syndrome (PCS). Symptoms typically resolve within 7-10 days, but a minority of patients report symptoms that persist for months or even years. The aim of our study was to identify a neurobiochemical marker after mTBI that can predict the presence of post-concussion syndrome three months after head injury in paediatric patients. <br><br>MATERIALS AND METHODS: Children between 7 and 16 years of age who had head trauma and no other complaints were included. Three months after the initial visit, participants or parents/guardians were interviewed in person about the children's PCS symptoms using the Rivermead Post-Concussion Symptoms Questionnaire (RPQ). <br><br>RESULTS: The mean value of S100B protein in serum in 38 patients without signs of PCS was 0.266 μg L(-1), with a 95% confidence interval (CI) of 0.221 - 0.310 μg L(-1). Among the 22 patients with signs of PCS, the mean value of S100B protein in serum was 0.845 μg L(-1), with a 95% CI of 0.745-0.945 μg L(-1). Patients with signs of PCS had higher S100B protein levels than those without signs of PCS (p < 0.0001). <br><br>CONCLUSIONS: Our prospective study showed that S100B protein is a useful neurobiomarker for detecting paediatric patients at risk for post-concussion syndrome. We found that the biomarker S100B correlated with the severity of traumatic brain injury (number of lesions on CT) and the presence of post-concussion syndrome.<p /> <p>Language: en</p>",
language="en",
issn="0268-8697",
doi="10.1080/02688697.2021.1878487",
url="http://dx.doi.org/10.1080/02688697.2021.1878487"
}