@article{ref1,
title="Behavioral and myelin-related abnormalities following blast-induced mild traumatic brain injury in mice",
journal="Journal of neurotrauma",
year="2021",
author="Nonaka, Mio and Taylor, William W. and Bukalo, Olena and Tucker, Laura T. and Fu, Amanda H. and Kim, Yeonho and McCabe, Joseph T. and Holmes, Andrew",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="In civilian and military settings, mild traumatic brain injury (mTBI) is a common consequence of impacts to the head, sudden blows to the body, and exposure to high-energy atmospheric shockwaves from the blast. In some cases, mTBI from blast exposure results in long-term emotional and cognitive deficits and an elevated risk for certain neuropsychiatric diseases. Here, we tested the effects of mTBI on various forms of auditory-cued fear learning and other measures of cognition in male C57BL/6J mice following single or repeated blast exposure (bTBI). bTBI produced an abnormality in the temporal organization of cue-induced freezing behavior in a conditioned trace fear test. Spatial working memory, evaluated by the Y-maze task performance, was also deleteriously affected by bTBI. RT-qPCR analysis for glial markers indicated an alteration in the expression of myelin-related genes in the hippocampus and corpus callosum one to eight weeks after bTBI. Immunohistochemical and ultrastructural analyses detected bTBI-related myelin and axonal damage in the hippocampus and corpus callosum. Together these data suggest a possible link between blast-induced mTBI, myelin/axonal injury, and cognitive dysfunction.<p /> <p>Language: en</p>",
language="en",
issn="0897-7151",
doi="10.1089/neu.2020.7254",
url="http://dx.doi.org/10.1089/neu.2020.7254"
}