@article{ref1,
title="Head injury and 25-year risk of dementia",
journal="Alzheimer's and dementia",
year="2021",
author="Schneider, Andrea L. C. and Selvin, Elizabeth and Latour, Lawrence and Turtzo, L. Christine and Coresh, Josef and Mosley, Thomas and Ling, Geoffrey and Gottesman, Rebecca F.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="INTRODUCTION: Head injury is associated with significant morbidity and mortality. Long-term associations of head injury with dementia in community-based populations are less clear. <br><br>METHODS: Prospective cohort study of 14,376 participants (mean age 54 years at baseline, 56% female, 27% Black, 24% with head injury) enrolled in the Atherosclerosis Risk in Communities (ARIC) Study. Head injury was defined using self-report and International Classification of Diseases, Ninth/Tenth Revision (ICD-9/10) codes. Dementia was defined using cognitive assessments, informant interviews, and ICD-9/10 and death certificate codes. <br><br>RESULTS: Head injury was associated with risk of dementia (hazard ratio [HR] = 1.44, 95% confidence interval [CI] = 1.3-1.57), with evidence of dose-response (1 head injury: HR = 1.25, 95% CI = 1.13-1.39, 2+ head injuries: HR = 2.14, 95% CI = 1.86-2.46). There was evidence for stronger associations among female participants (HR = 1.69, 95% CI = 1.51-1.90) versus male participants (HR = 1.15, 95% CI = 1.00-1.32), P-for-interaction < .001, and among White participants (HR = 1.55, 95% CI = 1.40-1.72) versus Black participants (HR = 1.22, 95% CI = 1.02-1.45), P-for-interaction = .008. <br><br>DISCUSSION: In this community-based cohort with 25-year follow-up, head injury was associated with increased dementia risk in a dose-dependent manner, with stronger associations among female participants and White participants.<p /> <p>Language: en</p>",
language="en",
issn="1552-5260",
doi="10.1002/alz.12315",
url="http://dx.doi.org/10.1002/alz.12315"
}