@article{ref1,
title="Lipids and essential fatty acids in patients presenting with self-harm",
journal="British journal of psychiatry",
year="2007",
author="Garland, Malcolm R. and Hallahan, Brian and McNamara, Melissa and Carney, Philip A. and Grimes, Helen and Hibbeln, J. R. and Harkin, Andrew and Conroy, Ronan M.",
volume="190",
number="",
pages="112-117",
abstract="BACKGROUND: Low cholesterol has been reliably demonstrated in people who self-harm. AIMS: To determine whether people who self-harm also have low levels of essential fatty acids (EFAs) and to examine associations between the EFAs and serotonergic function. METHOD: Depression, impulsivity and suicidal intent were measured in patients with self-harm (n=40) and matched controls, together with plasma lipids and EFAs. Platelet serotonergic studies were carried out in a subgroup (n=27). RESULTS: Patients with self-harm had significantly more pathology on all psychometric measures, lower mean total cholesterol levels (4.18 (s.d.=0.93) v. 4.87 (s.d.=0.83) mmol/l, P=0.003) and lower mean total EFA levels (89. 5 (15.6) v.103.7 (17.1) microg/ml, P=0.0001) than controls after adjustment for confounding variables. Total n-3 and n-6 EFA levels were also significantly lower. Impulsivity and depression scores were significantly inversely correlated with both n-6 EFAs and n-3 EFAs, but were not associated with total or low-density lipoprotein cholesterol levels. Platelet serotonergic measures did not differ between groups, and were not related to psychobiological measures. CONCLUSIONS: Lower plasma EFA levels combined with low cholesterol concentrations were associated with self-harm as well as impulsivity and affect. This was not related to platelet serotonergic measures.<p /> <p>Language: en</p>",
language="en",
issn="0007-1250",
doi="10.1192/bjp.bp.105.019562",
url="http://dx.doi.org/10.1192/bjp.bp.105.019562"
}