@article{ref1,
title="Serum lipids and suicidal risk among patients with schizophrenia spectrum disorders: systematic review and meta-analysis",
journal="Acta psychiatrica Scandinavica",
year="2021",
author="Sankaranarayanan, Anoop and Pratt, Robin and Anoop, Aparna and Smith, Angela and Espinoza, David and Ramachandran, Padmavati and Tirupati, Srinivasan",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVE: A systematic review of literature was conducted to determine the association between serum lipids and suicidality in people with schizophrenia spectrum disorders. <br><br>METHODS: We undertook a systematic search of multiple databases for studies that ascertained an association between serum lipids and suicidality in adult patients with schizophrenia spectrum disorders (18-65 years) from database inception to 2(nd) September 2020. Qualitative analysis was done using National Institute of Health (NIH) scales. The Standard Mean Difference (SMD) and 95% confidence intervals (CI) were calculated for each study and standardized relative to the study. Adjusted p-value, Z-test, and heterogeneity were calculated, as well as testing for publication bias. <br><br>RESULTS: Of 1262 records identified, 17 studies (n= 3113) were included in our systematic review, while 11 studies were included in the meta-analysis. The majority of studies (11) rated fair on qualitative analysis. Data from seven studies (n= 1597) revealed a medium effect size for an association between low total cholesterol and suicide attempts (SMD -0.560; 95% CI - 0.949 - 0.170; p =0.005). People with history of suicide attempt had a mean cholesterol value 0.56 SD lower than the mean in those without suicide attempts. There were differences in how a suicide attempt was defined and there was high heterogeneity (I(2) = 83.3%). No significant association was found between any of the serum lipid parameters and suicide ideation. Funnel-plot analysis suggested small study effects with publication bias. <br><br>CONCLUSIONS: Suicide attempts in people with schizophrenia spectrum disorders is associated with low mean total cholesterol levels.<p /> <p>Language: en</p>",
language="en",
issn="0001-690X",
doi="10.1111/acps.13305",
url="http://dx.doi.org/10.1111/acps.13305"
}