@article{ref1,
title="Higher negative self-reference level in patients with personality disorders and suicide attempt(s) history during biological treatment for major depressive disorder: clinical implications",
journal="Frontiers in psychology",
year="2021",
author="Bulteau, Samuel and Péré, Morgane and Blanchin, Myriam and Poulet, Emmanuel and Brunelin, Jerome and Sauvaget, Anne and Sébille, Véronique",
volume="12",
number="",
pages="e631614-e631614",
abstract="OBJECTIVE: The aim of the study was to identify clinical variables associated with changes in specific domains of self-reported depression during treatment by antidepressant and/or repetitive Transcranial Magnetic Stimulation (rTMS) in patients with Major Depressive Disorder (MDD). <br><br>METHODS: Data from a trial involving 170 patients with MDD receiving either venlafaxine, rTMS or both were re-analyzed. Depressive symptoms were assessed each week during the 2 to 6 weeks of treatment with the 13-item Beck Depression Inventory (BDI(13)). Associations between depression changes on BDI(13) domains (Negative Self-Reference, Sad Mood, and Performance Impairment), treatment arm, time, and clinical variables were tested in a mixed linear model. <br><br>RESULTS: A significant decrease of self-reported depressive symptoms was observed over time. The main characteristics associated with persistent higher depressive symptomatology on Negative Self-Reference domain of the BDI(13) were personality disorders (+2.1 points), a past history of suicide attempt(s) (+1.7 points), age under 65 years old (+1.5 points), and female sex (+1.1 points). <br><br>CONCLUSIONS: Early cognitive intervention targeting specifically negative self-referencing process could be considered during pharmacological or rTMS treatment for patients with personality disorders and past history of suicide attempt(s).<p /> <p>Language: en</p>",
language="en",
issn="1664-1078",
doi="10.3389/fpsyg.2021.631614",
url="http://dx.doi.org/10.3389/fpsyg.2021.631614"
}