@article{ref1,
title="Effects of cannabidiol and Δ9-tetrahydrocannabinol in the elevated plus maze in mice",
journal="Behavioural pharmacology",
year="2021",
author="Liu, Junhan and Scott, Brian W. and Burnham, Willets McIntyre",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="The present study tested the effects of cannabidiol (CBD) alone, Δ-9-tetrahydrocannabinol (THC) alone, and CBD and THC in combination (15:1 ratio) in the elevated plus maze (EPM), a test useful for the study of anxiety. In dose-response studies, adult, male CD1 mice were injected intraperitoneally with (1) CBD alone (0-96 mg/kg), (2) THC alone (0-6.4 mg/kg) or (3) CBD+THC in a 15:1 combination (0.0 + 0.0 mg/kg to 96.0 + 6.4 mg/kg). Diazepam (2.5 mg/kg) was also tested as a positive control. It was found that diazepam significantly increased open arm time in the EPM. CBD alone had no significant effect at any dose or injection-test interval. THC alone, however, caused a significant increase in open arm time at 3.2 and 6.4 mg/kg - doses which did not affect locomotion as measured by closed-arm entries. The effect of the combination of CBD and THC was not significantly different than the effect of THC alone. CBD alone did not have anxiolytic-like effects. THC had anxiolytic-like effects at nontoxic doses. No interaction between THC and CBD was seen when the two were combined.<p /> <p>Language: en</p>",
language="en",
issn="0955-8810",
doi="10.1097/FBP.0000000000000636",
url="http://dx.doi.org/10.1097/FBP.0000000000000636"
}