@article{ref1,
title="Case report: colchicine toxicokinetic analysis in a poisoned child requiring extracorporeal life support",
journal="Frontiers in pediatrics",
year="2021",
author="Pérez Marín, Maria and Prod'hom, Sylvain and de Villiers, Suzanne Francesca and Ferry, Thomas and Amiet, Vivianne and Natterer, Julia and Perez, Maria-Helena and Buclin, Thierry and Chtioui, Haithem and Longchamp, David",
volume="9",
number="",
pages="e658347-e658347",
abstract="Colchicine poisoning is associated with a poor prognosis, especially when leading to shock and multi-organ failure, and management is limited to supportive care, including multiple-dose activated charcoal. At therapeutic concentrations, colchicine elimination occurs mainly through hepatic metabolism and involves an enterohepatic circulation, with a small contribution of renal elimination (10-30%). Colchicine toxicokinetics is however rarely described, especially in children. We present the case of a 4-year-old patient who survived a severe iatrogenic colchicine intoxication with a dose of 0.5 mg/kg. She developed multi-organ failure and shock, but recovered after receiving aggressive resuscitation, including extracorporeal life support. Close monitoring of colchicine blood levels showed a plateau for 6 days, indicating impeded elimination resulting from liver failure. We observed no significant clearance from renal replacement therapy, nor activated charcoal, during this period. Extracorporeal life support may play a supportive role in the management of severe colchicine poisoning. However, extracorporeal techniques do not seem to improve colchicine elimination.<p /> <p>Language: en</p>",
language="en",
issn="2296-2360",
doi="10.3389/fped.2021.658347",
url="http://dx.doi.org/10.3389/fped.2021.658347"
}