@article{ref1,
title="A longitudinal study of white matter functional network in mild traumatic brain injury",
journal="Journal of neurotrauma",
year="2021",
author="Jia, Xiaoyan and Chang, Xuebin and Bai, Lijun and Wang, Yulin and Dong, Debo and Gan, Shuoqiu and Wang, Shan and Li, Xuan and Yang, Xuefei and Sun, Yingxiang and Li, Tianhui and Xiong, Feng and Niu, Xuan and Yan, Hao",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Some patients after mild traumatic brain injury (mTBI) results in microstructural damages in the long-distance white matter (WM) connections and thus disrupts the functional connectome of large-scale brain networks that support cognitive function. Patterns of WM structural damage following mTBI were well documented using diffusion tensor imaging (DTI), however, the functional organization of WM and its association with grey matter functional networks (GM-FNs) and its DTI metrics remains unknown. The present study adopted resting-state functional magnetic resonance imaging to explore WM functional properties in mTBI patients (108 acute patients, 48 chronic patients, 46 healthy controls (HCs)). Eleven large-scale WM functional networks (WM-FNs) were constructed by the k-means clustering algorithm which carried out in voxel-wise WM functional connectivity (FC). Compared to HCs, acute mTBI patients observed enhanced FC between inferior fronto-occipital fasciculus (IFOF) WM-FN and primary sensorimotor WM-FNs, and cortical primary sensorimotor GM-FNs. Besides, acute mTBI patients showed increased DTI metrics (mean diffusivity, axial diffusivity, and radial diffusivity) in deep WM-FNs and higher-order cognitive WM-FNs. Moreover, mTBI patients demonstrated full recovery of FC and partial recovery of DTI metrics in the chronic stage. Additionally, enhanced FC between IFOF WM-FN and anterior cerebellar GM-FN was correlated with impaired information processing speed. Our findings provide novel evidence for functional and structural alteration of WM-FNs in mTBI patients. Importantly, the convergent damage of the IFOF network might imply its crucial role in our understanding of the pathophysiology mechanism of mTBI patients.<p /> <p>Language: en</p>",
language="en",
issn="0897-7151",
doi="10.1089/neu.2021.0017",
url="http://dx.doi.org/10.1089/neu.2021.0017"
}