@article{ref1,
title="Formate test for bedside diagnosis of methanol poisoning",
journal="Basic and Clinical Pharmacology and Toxicology",
year="2021",
author="Hovda, Knut Erik and Lao, Yvonne Elisabeth and Gadeholt, Gaut and Jacobsen, Dag",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Methanol poisoning kills thousands of people every year and remains a diagnostic challenge, especially where the resources are scarce, but also in high-income countries worldwide. We are in the course of developing a bedside strip to detect formate - the toxic metabolite of methanol. We hereby present the first clinical methanol case where formate was detected bedside from a drop of blood: The patient, a 61-year-old male, was admitted with a suspect methanol poisoning and severe metabolic acidosis. The test strip was positive after 3 minutes. Sodium bicarbonate (500mmol/L), fomepizole, dialysis, and folinic acid were given based on the positive test. The diagnosis was some hours later confirmed by GC-MS, showing a methanol concentration of 62 mmol/L (200 mg/dL) and a formate concentration of 19 mmol/L. Implementation of this technology into routine clinical use can potentially offer an opportunity for a step-change in the management of methanol poisoning.<p /> <p>Language: en</p>",
language="en",
issn="1742-7835",
doi="10.1111/bcpt.13597",
url="http://dx.doi.org/10.1111/bcpt.13597"
}