@article{ref1,
title="Intergenerational effects of maternal post-traumatic stress disorder on offspring epigenetic patterns and cortisol levels",
journal="Epigenomics",
year="2021",
author="Hjort, Line and Rushiti, Feride and Wang, Shr-Jie and Fransquet, Peter and Krasniqi, Sebahate P. and Çarkaxhiu, Selvi I. and Arifaj, Dafina and Xhemaili, Vjosa Devaja and Salihu, Mimoza and Leku, Nazmie A. and Ryan, Joanne",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="AIM: To investigate the association between maternal post-traumatic stress disorder (PTSD) during pregnancy and offspring DNA methylation and cortisol levels. Materials & methods: Blood genome-wide DNA methylation and cortisol was measured in the youngest child of 117 women who experienced sexual violence/torture during the Kosovo war. <br><br>RESULTS: Seventy-two percent of women had PTSD symptoms during pregnancy. Their children had higher cortisol levels and differential methylation at candidate genes (NR3C1, HTR3A and BNDF). No methylation differences reached epigenome-wide corrected significance levels. <br><br>CONCLUSION: Identifying the biological processes whereby the negative effects of trauma are passed across generations and defining groups at high risk is a key step to breaking the intergenerational transmission of the effects of mental disorders.<p /> <p>Language: en</p>",
language="en",
issn="1750-1911",
doi="10.2217/epi-2021-0015",
url="http://dx.doi.org/10.2217/epi-2021-0015"
}