@article{ref1,
title="Event related potentials indexing the influence of emotion on cognitive processing in veterans with comorbid post-traumatic stress disorder and traumatic brain injury",
journal="Clinical neurophysiology",
year="2021",
author="Campbell, Alana M. and Elbogen, Eric B. and Johnson, Jacqueline L. and Hamer, Robert M. and Belger, Aysenil",
volume="132",
number="7",
pages="1389-1397",
abstract="OBJECTIVE: Emotion regulation and cognitive executive control are significantly impaired in both post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI). These illnesses are increasingly common in veterans and their co-occurrence may exacerbate symptoms and recovery. The current study sought to investigate neural correlates of these impairments via event-related potentials (ERPs) and examined the association of PTSD symptom severity and impulsivity with these correlates. <br><br>METHODS: Electroencephalographic data from seventy-nine veterans with PTSD and TBI and 17 control participants were recorded during a visual emotional oddball task and analyzed for the N2 and P3b ERPs. <br><br>RESULTS: Results revealed that veterans showed a reduced P3b ERP in response to both target images and standard images. However, for standard images that followed a negative emotional distractor, the veterans showed a heightened N2 amplitude while the controls did not. In addition, impulsivity predicted modulation of the P3b across stimulus conditions, with a greater P3b amplitude associated with an increase in impulsivity. <br><br>CONCLUSIONS: These findings suggest that veterans showed hyper-responsivity to background information and reduced ERPs to task-relevant information. SIGNIFICANCE: These findings may reflect heightened internal states that create neural noise and a reduced ability to modulate relevant responses.<p /> <p>Language: en</p>",
language="en",
issn="1388-2457",
doi="10.1016/j.clinph.2021.03.017",
url="http://dx.doi.org/10.1016/j.clinph.2021.03.017"
}