@article{ref1,
title="White matter disruption in pediatric traumatic brain injury: results from ENIGMA pediatric moderate to severe traumatic brain injury",
journal="Neurology",
year="2021",
author="Dennis, Emily L. and Caeyenberghs, Karen and Hoskinson, Kristen R. and Merkley, Tricia L. and Suskauer, Stacy J. and Asarnow, Robert F. and Babikian, Talin and Bartnik-Olson, Brenda and Bickart, Kevin and Bigler, Erin D. and Ewing-Cobbs, Linda and Figaji, Anthony and Giza, Christopher C. and Goodrich-Hunsaker, Naomi J. and Hodges, Cooper B. and Hovenden Aa, Elizabeth S. and Irimia, Andrei and Königs, Marsh and Levin, Harvey S. and Lindsey, Hannah M. and Max, Jeffrey E. and Newsome, Mary R. and Olsen, Alexander and Ryan, Nicholas Peter and Schmidt, Adam T. and Spruiell, Matthew S. and Wade, Benjamin Sc and Ware, Ashley L. and Watson, Christopher G. and Wheeler, Anne L. and Yeates, Keith Owen and Zielinski, Brandon A. and Kochunov, Peter and Jahanshad, Neda and Thompson, Paul M. and Tate, David F. and Wilde, Elisabeth A.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVE: Our study addressed aims: (1) test the hypothesis that moderate-severe TBI in pediatric patients is associated with widespread white matter (WM) disruption; (2) test the hypothesis that age and sex impact WM organization after injury; and (3) examine associations between WM organization and neurobehavioral outcomes. <br><br>METHODS: Data from ten previously enrolled, existing cohorts recruited from local hospitals and clinics were shared with the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Pediatric msTBI working group. We conducted a coordinated analysis of diffusion MRI (dMRI) data using the ENIGMA dMRI processing pipeline. <br><br>RESULTS: Five hundred and seven children and adolescents (244 with complicated mild to severe TBI [msTBI] and 263 controls) were included. Patients were clustered into three post-injury intervals: acute/subacute - <2 months, post-acute - 2-6 months, chronic - 6+ months. Outcomes were dMRI metrics and post-injury behavioral problems as indexed by the Child Behavior Checklist (CBCL). Our analyses revealed altered WM diffusion metrics across multiple tracts and all post-injury intervals (effect sizes ranging between d=-0.5 to -1.3). Injury severity is a significant contributor to the extent of WM alterations but explained less variance in dMRI measures with increasing time post-injury. We observed a sex-by-group interaction: females with TBI had significantly lower fractional anisotropy in the uncinate fasciculus than controls ...  Keywords: Social Transition",
language="en",
issn="0028-3878",
doi="10.1212/WNL.0000000000012222",
url="http://dx.doi.org/10.1212/WNL.0000000000012222"
}