@article{ref1,
title="Predictors of disability in adolescents and young adults with acquired brain injury after the acute phase",
journal="Brain injury",
year="2021",
author="Worm, M. S. and Valentin, J. B. and Johnsen, S. P. and Nielsen, Jørgen Feldbaek and Forchhammer, H. B. and Svendsen, Susanne Wulff",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="AIM: To develop and validate a prediction model for disability among young patients with acquired brain injury (ABI) after the acute phase.<br><br>METHODS: Within a nationwide cohort of 446 15-30-year-old ABI-patients, we predicted disability in terms of Glasgow Outcome Scale - Extended (GOS-E) <7 12 months after baseline assessment in outpatient neurorehabilitation clinics. We studied 22 potential predictors covering demographic and medical factors, clinical tests, and self-reported fatigue and alcohol/drug consumption. The model was developed using multivariable logistic regression analysis and validated by 5-fold cross-validation and geographical validation. The model's performance was assessed by receiver operating characteristic curves and calibration plots.<br><br>RESULTS: Baseline assessment took place a median of 12 months post-ABI. Low GOS-E (range 1-8 (best)) and Functional Independence Measure (range 18-126 (best)) along with high mental fatigue (range 4-20 (worst)) predicted disability. The model showed high validity and performance with an area under the curve of 0.82 (95% confidence interval (CI) 0.77, 0.87) in the cross-validation and 0.81 (95% CI 0.73, 0.88) in the geographical validation.<br><br>CONCLUSION: We developed and validated a parsimonious model which effectively predicted disability. The model may be useful to guide decision-making in outpatient neurorehabilitation clinics treating young patients with ABI.<p /> <p>Language: en</p>",
language="en",
issn="0269-9052",
doi="10.1080/02699052.2021.1927183",
url="http://dx.doi.org/10.1080/02699052.2021.1927183"
}