@article{ref1,
title="Outcomes of elderly patients with organophosphate intoxication",
journal="Scientific reports",
year="2021",
author="Yu, Jia-Ruei and Hou, Yi-Chou and Fu, Jen-Fen and Wang, I.-Kuan and Chan, Ming-Jen and Chen, Chao-Yu and Weng, Cheng-Hao and Huang, Wen-Hung and Yang, Huang-Yu and Hsu, Ching-Wei and Yen, Tzung-Hai",
volume="11",
number="1",
pages="11615-11615",
abstract="This study analysed the clinical patterns and outcomes of elderly patients with organophosphate intoxication. A total of 71 elderly patients with organophosphate poisoning were seen between 2008 and 2017. Patients were stratified into two subgroups: survivors (n = 57) or nonsurvivors (n = 14). Chlorpyrifos accounted for 33.8% of the cases, followed by methamidophos (12.7%) and mevinphos (11.3%). Mood, adjustment and psychotic disorder were noted in 39.4%, 33.8% and 2.8% of patients, respectively. All patients were treated with atropine and pralidoxime therapies. Acute cholinergic crisis developed in all cases (100.0%). The complications included respiratory failure (52.1%), aspiration pneumonia (50.7%), acute kidney injury (43.7%), severe consciousness disturbance (25.4%), shock (14.1%) and seizures (4.2%). Some patients also developed intermediate syndrome (15.5%) and delayed neuropathy (4.2%). The nonsurvivors suffered higher rates of hypotension (P < 0.001), shock (P < 0.001) and kidney injury (P = 0.001) than survivors did. Kaplan-Meier analysis indicated that patients with shock suffered lower cumulative survival than did patients without shock (log-rank test, P < 0.001). In a multivariate-Cox-regression model, shock was a significant predictor of mortality after intoxication (odds ratio 18.182, 95% confidence interval 2.045-166.667, P = 0.009). The mortality rate was 19.7%. Acute cholinergic crisis, intermediate syndrome, and delayed neuropathy developed in 100.0%, 15.5%, and 4.2% of patients, respectively.<p /> <p>Language: en</p>",
language="en",
issn="2045-2322",
doi="10.1038/s41598-021-91230-2",
url="http://dx.doi.org/10.1038/s41598-021-91230-2"
}